Mr. Preuss is the former president and founder of Integrated Software Systems Corporation (ISSCO), a leading supplier of computer graphics software, which he led from 1970 to 1986, when it was sold (Nasdaq: ISCX).
He is a Regent Emeritus of the University of California having served on its board from 1993 through 2008. He is the President of The Preuss Foundation for Brain Tumor Research, a private foundation specializing in support of research and fostering communication among scientists.
Mr. Preuss was a founder and long-time director of the National Computer Graphics Association. Some of the companies he serves or has served on the Board of Directors are: Biosym Technologies, Inc., CENTRAX Corporation, Dr. Design, Inc., DepoTech Corporation (DEPO), DOME Imaging Systems, Inc., EGEA Biosciences, Inc., Everyone Counts, Inc., GPC-Biotech Gmbh, Network Computing Devices, Inc. (NCDI), Overland Storage, Inc., Scripps Translational Science Institute Advisory Board, Sierra Geophysics, Inc., Execucom, Westec Services, and Wright Strategies, Inc.
He has served a term on the Advisory Committee to the Director of the National Institutes of Health in Washington, DC. He also serves or has served on the boards of The Sanford Burnham Medical Research Institute, The National Brain Tumor Foundation, Duke University Cancer Center Board of Overseers, the Board of Overseers of the University of California, San Diego, Board of Overseers, Dartmouth Medical School, and the California Council on Science and Technology. He is a past president of the University of California, San Diego Cancer Center Foundation.